Recently, FAT atypical cadherin 3 (FAT3), kinectin 1 (KTN1), discs large homolog 2 (DLG2) and deleted in colorectal cancer (DCC) have been reported to be associated with the function of the human mesolimbic reward system [6], which is the neurobiological basis of drug addiction. This evidence concerns the gene FAT3 and colorectal cancer.