Interestingly, when we checked the distribution of the plasma concentration of apoA2-ATQ/ATQ, which is a heavy isoform (MW, 17,380 Da), and that of apoA2-AT/AT, which is a light isoform (MW, 17,124 Da), in patients with PDAC, apoA2-ATQ/ATQ and apoA2-AT/AT showed reciprocal distributions in pancreatic cancer in comparison with healthy controls. Here, APOA2 is linked to familial pancreatic carcinoma.