ESR1 and sarcoma: For example, the cancer related phenotypes (e.g. “adenocarcinoma”, “malignant soft tissue neoplasm“, and “sarcoma“) linked to tamoxifen treatment as well as to mice with impaired TP53 protein function might be due to the effect of the drug on the function/activity of p53 protein, for example, via a cooperative effect with its target, the estrogen receptor [33].