One study in T2DM demonstrated that KIM-1 predicted the decline of GFR in unadjusted analysis [24] and two studies in T1DM also showed that KIM-1 levels were significantly higher in the patients who progressed from nonmacroalbuminuria to CKD stage 3 [25] and macroalbuminuria to late stage of CKD [26]. The gene discussed is HAVCR1; the disease is type 2 diabetes mellitus.