ITGB1BP2 and dilated cardiomyopathy: A genetic screening for Melusin mutations in cardiomyopathic patients, performed by three independent laboratories, have revealed two missense mutations, a His13Tyr mutation in the CHORD I domain in a family with hypertrophic cardiomyopathy (Palumbo et al., 2009), and an Ala313Gly mutation in the carboxy terminal region linking the CS domain to the acidic domain in a family with dilated cardiomyopathy (Ruppert et al., 2013) but their segregation in the family members not always correlates with the onset of cardiomyopathy, making their causative significance unclear.