ITGB1BP2 and dilated cardiomyopathy: Instead, upon pressure overload conditions, Melusin overexpression effectively protects mouse myocardium by sustaining the compensatory hypertrophic response and healthy contractile function even after 12 weeks of aortic banding, when wild-type mice have already developed a dilated cardiomyopathy and heart failure (De Acetis et al., 2005).