IL1 is also known to involve in the neurodegeneration of acute and chronic brain disorders, including ischemic stroke, Alzheimer’s disease and Parkinson’s disease, although the cytokine is thought to be involved in the recovery of neurological functions (Dinarello, Simon & Van der Meer, 2012; Kostulas et al., 1999). Here, IL1B is linked to early-onset autosomal dominant Alzheimer disease.