Given the essential role for the p110α catalytic subunit of PI3K in transducing oncogenic signals downstream of upregulated or mutated RTKs and oncogenes such as Ras in hematological malignancies [16], it seemed a likely candidate but it was also possible that p110β which is known to be activated by PTEN loss or p110δ might also be contributing [6, 17]. This evidence concerns the gene PIK3CD and hematologic disorder.