Moreover, in other studies, it was found that Ngb is expressed in microglia and astrocytes specifically during conditions such as traumatic brain injury (84, 122) and that estradiol regulates the expression of Ngb in astrocytes (66) through the estrogen receptor β (ERβ) (22), while ERα is involved in the regulation of Ngb in neurons (137). The gene discussed is NGB; the disease is injury.