CALR and cancer: Physiologically, CRT was first described as an endoplasmic reticulum protein responsible for Ca2+ homeostasis and glycoprotein folding; currently, CRT is recognized as a multifunctional chaperone detected in other cellular compartments, as well as extracellularly, where it is involved in cell proliferation, phagocytosis, apoptosis, adhesion, and innate and adaptive immune processes including cancer cell elimination by immunogenic cell death and fibrosis [13].