Consistent with our study, it was reported that TBL1XR1 was elevated in lung squamous cell cancer, esophageal squamous cell cancer, cervical cancer, breast cancer, nasopharyngeal cancer, and hepatocellular carcinoma [10–14, 20], suggesting that TBL1XR1 upregulation might be a common event in the progression of different cancers. Here, TBL1XR1 is linked to breast cancer.