The results showed that high expression of TBL1XR1 was an independent prognostic factor for poor overall survival (hazard ratio, 0.525; 95% confidence interval, 0.367–0.752; P = 0.005), as well as histological type, TNM stage, and lymph node metastasis status (P = 0.048, P = 0.000, and P = 0.001, resp). This evidence concerns the gene TBL1XR1 and metastatic malignant neoplasm in the lymph nodes.