In the present study, we demonstrated the oncological significance of TBL1XR1 in GC patients: (a) the expression of TBL1XR1 was significantly elevated in primary gastric tumor and lymph node tissues; (b) high levels of TBL1XR1 were associated with lymph node metastasis and advanced TNM stage; (c) TBL1XR1 overexpression is a negative predictor of prognosis in GC patients. Here, TBL1XR1 is linked to gastric neoplasm.