β-adrenergic antagonists and ACE inhibitors, which increase PNS and reduce SNS activity, could be favorable in young patients with reduced parasympathetic activity.31 In addition, simple lifestyle modifications leading to weight loss increase cardiac vagal drive and reduce sympathetic nerve activity and BP in young subjects.32 We have identified some possible early mechanisms for hypertension and aortic stiffening in young people, and this may be useful in targeting drug interventions and developing novel therapeutics for the treatment of hypertension in the young subjects. This evidence concerns the gene ACE and hypertensive disorder.