TGFA and obesity due to melanocortin 4 receptor deficiency: IL-6 is regarded as a pleiotropic cytokine which may have both inflammatory and antiinflammatory effects, IL-10 is a well-known antiinflammatory cytokine, adiponectin is an adipokine that suppresses metabolic derangements associated with obesity/T2D, FLT-3 L is a growth factor for hematopoietic progenitors, and TGF-α is a mitogenic polypeptide that acts as a ligand for EGFR/HER-1 to activate signaling pathways for cell proliferation, differentiation, and development [21–23].