Fetuin-A, also known as α-2 Heremans-Schmid glycoprotein (AHSG), is a member of cystatin superfamily of protease inhibitors and is a major human secretory protein of hepatic origin with multiple normal biological as well as pathological functions including inhibition of vascular calcification, bone metabolism regulation, control of protease activity, insulin resistance, keratinocyte migration, and breast tumor cell proliferative signaling [1]. Here, AHSG is linked to breast neoplasm.