These are TSHZ2 (known to be down-regulated in breast and prostate cancer44), ITIH5 (promoter methylation is an early breast cancer detection biomarker41), GREB1 (estrogen regulator42, 43), MEG3 (long non-coding RNA known to be down-regulated in cancer34, 35), and RELN (methylated and down-regulated in pancreatic cancer, where its expression has been associated with increased cell motility, invasiveness and colony-forming ability45 but has not been described in breast cancer). The gene discussed is TSHZ2; the disease is familial pancreatic carcinoma.