As cytokines have already been shown to be associated with AD, the aim of this study was to further elucidate the role of cytokines in AD by simultaneous assessment of IL-1β, IL-8 and TNF-α levels in serum and CSF samples of AD patients compared with age-matched controls and to investigate whether these cytokines correlate with cognitive performance. The gene discussed is IL1B; the disease is Alzheimer disease.