In the present study, we also showed that overexpression of the miR-342, which targets the 3′-UTR (untranslated region) of IA-2, results in a decrease in the expression of IA-2 mRNA and, in turn, a decrease in the cellular content and secretion of ACh resulting in a decrease in the growth of SCLC cells (Fig. 6). The gene discussed is PTPRN; the disease is small cell lung carcinoma.