The homozygous point mutation of p.G1310C introduces a substitution of Glycine to Cystine in the exon 11 of the CRB1 protein and is predicted probably to be damaging to the protein function through the C-type lectin domain (SIFT score is 0.002 and PolyPhen2 scores close to 1.0), thus causing retinitis pigmentosa in the Indian RP patient. This evidence concerns the gene CRB1 and retinitis pigmentosa.