And the prevalence of CRB1 mutations varies widely depending on the clinical phenotype and the cohort studied, ranging between 7% in EORD patients30, 10% in LCA patients18, 31% in RP patients with Coats-like exudative vasculopathy and 66% in RP patients with PPRPE31. The gene discussed is CRB1; the disease is Leber congenital amaurosis.