More widely, siRNA-mediated silencing of stathmin has been shown to suppress the proliferation, invasion and metastasis of nasopharyngeal carcinoma (NPC) cells [60], hepatoma [4], retinoblastoma [86], endometrial carcinoma [33], bladder cancer [36] and glioma [89], and significantly induces the apoptosis of tumor cells [54, 60, 62]. This evidence concerns the gene STMN1 and retinoblastoma.