Of the 45 extreme ASE events observed in CHD probands (Supplementary Table 6), seven ASE events (Table 2) resulted from nonsense (ASPN, CTSA, PGM1 and RBFOX2), splice site (AARSD1) or frameshift (C7 and RETSAT) variants that caused NMD. This evidence concerns the gene CTSA and coronary artery disorder.