The acute presentation (pre-recruitment) mean CRP concentrations were higher in severe AP, but this difference was not statistically significant (CRP concentration, median (IQR): mild: 11 (5–34) mg/L; moderate: 19 (9–39) mg/L; severe: 59 (30–65) mg/L; P = 0.166) (Fig. 4a and Supplementary Table S3). The gene discussed is CRP; the disease is alkaline phosphatase measurement.