CRP and alkaline phosphatase measurement: A clear rise in CRP level was evident for tAP participants (standardized AUC for CRP concentration, median (IQR): hyperamylasaemia participants: 18.9 (5.75–45.4) mg/L; tAP participants: 126.0 (49.9–201.1); P < 0.001), the magnitude of which was proportionate to AP severity (Fig. 4a) and in keeping with a substantial systemic inflammatory insult (standardized AUC for CRP concentration, median (IQR): mild: 58.9 (26.3–131.2) mg/L; moderate: 148.1 (74.5–243.9) mg/L; severe: 225.6 (174.9–260.2) mg/L; P = 0.001).