The EGFR ligands: epidermal growth factor (EGF), transforming growth factor-α (TGFA), heparin-binding EGF-like growth factor (HBEGF), amphiregulin (AREG), beta-cellulin (BTC), epiregulin (EREG) and epigen (EPGN), may increase tumor growth, invasion, and metastasis through EGFR activation [5]. The gene discussed is HBEGF; the disease is neoplasm.