SOX2-OT and esophageal squamous cell carcinoma: SOX2OT has been associated with carcinogenesis and, for example in breast cancer is involved in the induction and/or maintenance of SOX2 expression [59], in esophageal squamous cell carcinoma has been shown to play a role in tumor initiation and/or progression as well as in regulation of the pluripotent state of stem cells [58], and proliferation in lung cancer cells [60].