The results that the RIPK3-deficient mice developed pristane-induced lupus, which is IFN-I dependent [28] as the B6 mice do, demonstrates that RIPK3 is not involved in this model of type-I interferon-mediated autoimmunity and confirms the results from the cGvHD model that RIPK3 is not involved in autoantibody production. This evidence concerns the gene RIPK3 and systemic lupus erythematosus.