In this paper, we have investigated the role of RIP3 in three inducible murine models of lupus and nephritis, which allowed us to test three important pathogenic steps in lupus, i.e., the production of autoantibodies, the IFN-I-dependent activation of the innate and adaptive immune response and the induction of cell death. This evidence concerns the gene RIPK3 and systemic lupus erythematosus.