The aberrant activity of ALK fusions, as a consequence of chromosomal rearrangements, leads to the development of multiple malignancies such as non-small cell lung cancer (NSCLC) [6] and ALK-positive ALCL [7] (the latter representing ∼ 50–80% of all ALCLs [8] of which in ∼ 85% ALK is fused with NPM [9]). The gene discussed is ALK; the disease is non-small cell lung carcinoma.