XPC and colorectal cancer: Of these coding region SNPs, XPC Lys939Gln (rs2228001 A > C) and Ala499Val (rs2228000 C > T) polymorphisms have been foci of interest for their potential function, as well as association with the risk of various types of cancer, including breast cancer, lung cancer, bladder cancer, and colorectal cancer (CRC) [8].