CD58 and neoplasm: The recombinant virus used in fowlpox-TRICOM expresses three costimulatory transgenes, B7.1 (CD80), Intercellular Adhesion Molecule 1 (ICAM-1), and lymphocyte function-associated antigen 3 (LFA-3), plus one or more tumor-associated antigens, such as Carcinoembryonic antigen (CEA) and MUC-1 [80].