Impairment in the secretion of GLP-1 has been considered in the pathophysiology of type 2 diabetes and the administration of GLP-1 receptor agonists, which restores GLP-1 function has been shown to promote insulin secretion, sensitivity and enhance long term prognosis including reduction in cardiovascular risks and complications [14]. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.