The differences between the RDEB and other EB patients were statistically significant for all studied anti-skin antibodies (p < 0.001, p = 0.019, p = 0.015 and p < 0.001 for DSG3, BP180, BP230 and COL7, respectively), with the exception of anti-DSG1 (p = 0.066) after correction with the Benjamini-Hochberg procedure. This evidence concerns the gene DSG3 and epidermolysis bullosa.