All anti-skin antibodies were significantly higher in the EB patients than in the controls (p = 0.008, p < 0.001, p < 0.001, p < 0.001 and p < 0.001 for desmoglein 1 (DSG1), desmoglein 3 (DSG3), bullous pemphigoid 180 (BP180), BP230 and type VII collagen (COL7), respectively). This evidence concerns the gene DSG3 and epidermolysis bullosa.