ITGAL and systemic lupus erythematosus: It has been shown that autoimmune responses in SLE may partly be explained by Regulatory factor X-box 1 (RFX1) downregulation, which results in histone H3 hyperacetylation at the promoter region of CD11a and CD70 genein CD4+ T cells of patients with systemic lupus erythematosus (SLE).