PPARG and obesity due to melanocortin 4 receptor deficiency: More recently, the anti-obesity effects of Lysimachia foenum-graecum (LFE) were associated with its ability to block adipogenesis in 3T3-L1 adipocytes through the possible link between LFE-induced activation of AMPK and AMPK-mediated suppression of PPARγ transcriptional activity [38].