INS and type 2 diabetes mellitus: There were no differences in age, BMI, body fat %, systolic and diastolic blood pressure, waist-hip ratio, plasma fasting glucose, serum fasting insulin, vertebral bone marrow (VBM) fat/water ratio, whole body insulin sensitivity (M-value) or prevalence of T2D between control vs frail, control vs OLM, control vs OOM and OLM vs OOM (Table 1).