However, in contrast to normal SPC profiles, and despite immunophenotypic heterogeneity, co-existing CD34+CD38low and CD34+CD38high leukemic-SPCs in AML BM samples often had similar intracellular ROS levels (examples of LMPP/GMP-like and MPP/CMP-like AML in Fig 1C, and additional examples in S1F Fig). Here, CD34 is linked to acute myeloid leukemia.