In the case of colon cancer treated with surgery, CXCR4 and Bcl-2 protein expression may be a predictor of tumor cell invasion and metastasis[10–11], which are associated with EMT phenotype and creating chemoresistance, processes that involve the activation of the pathways associated with phosphatidylinositol 3-kinase/Akt, extracellular regulated kinase (ERK), and NF-kappaB by tumor cells or by surrounding stromal cells [12–13]. This evidence concerns the gene CXCR4 and malignant colon neoplasm.