Moreover, drug-treated Cdh16Cre::Tfebfs animals showed a significant decrease in the mRNA levels of Gpnmb, a known marker of melanomas, gliomas and breast cancer, which was reported to be overexpressed in TFE-fusion ccRCCs (Malouf et al., 2014; Zhou et al., 2014). This evidence concerns the gene GPNMB and central nervous system cancer.