TFE3 and hereditary clear cell renal cell carcinoma: TFE-RCCs are a group of renal cell carcinomas caused by chromosomal translocations involving TFEB and TFE3 genes (Kauffman et al., 2014) and representing around 2% of all RCCs (Komai et al., 2009), and almost 12% of papillary type II RCCs (Linehan et al., 2015).