Strikingly, cell proliferation was significantly dampened, in a dose-dependent way, by two small-molecules, PKF118-310 and CGP049090 that specifically inhibit the WNT pathway by disrupting the interaction between β-catenin and TCF4 (Avila et al., 2006) and are known to suppress cell proliferation in several types of cancers, both in vitro and in vivo (Wei et al., 2010; Wakita et al., 2001) (Figure 5D). The gene discussed is TCF4; the disease is cancer.