CD4 and HIV infectious disease: Will HIV cure normalize the perturbed immune homeostasis and the inflammatory/procoagulant state of treated HIV infection? As noted above, many persons with ART-suppressed infection maintain low circulating CD4 T cell numbers, increased circulating CD8 T cell counts, and an increased proinflammatory and procoagulant state that have been linked to ART-era morbidity and mortality [14, –16].