Here, we perform the first SNP replication study on previously published SNPs within SNCA (rs356221, rs2301134, and rs2301135), LRRK2 (rs1491942), and ITGA8 (rs7077361) gene in Chinese Han population to explore the ethnic differences and recognize predictive factors for the diagnosis of PD. This evidence concerns the gene LRRK2 and Parkinson disease.