These scientific findings are reminiscent of the TCM theory of “Kidneys Govern Bones.” The clinical manifestations of Kidney Essence Deficiency, including fatigue, delayed growth and development, pain and weakness in lower back and knees, and early aging [2], are strikingly similar to the phenotype of Klotho deficiency. This evidence concerns the gene KL and hyperinsulinemic hypoglycemia, familial, 4.