Ouabain indeed does activate Src in myocytes (Haas et al., 2000; Mohammadi et al., 2001, 2003; Xie and Askari, 2002; Liu et al., 2003, 2004) and several lines of evidence support the finding that the Na+/K+-ATPase and Src do interact and induced by ouabain or high salt by immunoprecipitation assay in cardiomyocytes, breast cancer cells, and primary pig proximal tubular cells and LLC-PK1 cells (Mohammadi et al., 2003; Kometiani et al., 2005; Liu et al., 2011; Yan et al., 2013). Here, SRC is linked to breast cancer.