VNN1 and Insulin resistance: Overexpression of Vanin-1 leads to enhanced hepatic gluconeogenesis, elevated blood glucose, and insulin resistance in C57BL/6 mice64 Further, the knock-down of Vanin-1 in db/db mice, which have elevated Vanin-1 expression and are prone to hepatic steatosis, led to the attenuation of hepatic steatosis64.