In the third example, endometrial cancer signatures (GSE17025) are shown to cluster with estradiol signatures derived from MCF7 cells from multiple independent studies (GSE4668, GSE11352, GSE53394), as well as MIR34A overexpression signature from HCT116 cells (GSE7754), PPARG overexpression signature from NIH-3T3 cells (GSE2192), and IGF1 stimulation signature from MCF7 cells (GSE7561) (Fig. 4d). The gene discussed is IGF1; the disease is endometrial cancer.