CLOCK and cancer: Previous genetic association studies have proven that there are three functional single nucleotide polymorphisms in the CLOCK sequence linked to cancer and phenotype, these include: rs11133373 C/G and rs11133391 T/C, linked to prostate and breast cancer, and rs1801260 T/C, linked to several phenotypes, such as sleep disturbance, mood weight loss bipolar disorders, breast and CRC2, 4, 6, 7, 8, 9.