Furthermore, although Lcn2 mRNA levels were significantly increased by treatment with lipopolysaccharide (LPS) (100 ng/ml) or ethanol (50 mM), co-incubation with FGF19 (50 ng/ml) completely abolished the ability of LPS or ethanol to induce Lcn2 gene expression in AML-12 cells (Supplementary Fig. S1). The gene discussed is FGF19; the disease is acute myeloid leukemia.