TDRG1 and obesity due to melanocortin 4 receptor deficiency: The four significantly associated host genetic variants in FHIT, ELAVL4 and TDRG1 were not the same as the lead SNPs for each candidate obesity locus reported in Locke et al. [8], and are in low to moderate linkage disequlibrium (LD) with the corresponding lead SNPs (r2 = 0.014–0.25).