本研究旨在应用基质辅助激光解析离子化-时间飞行质谱仪(matrix-assisted laser desorption ionization time-of-?ight mass spectrometry, MALDI-TOF-MS)检测晚期非小细胞肺癌(non-small cell lung cancer, NSCLC)患者在接受表皮生长因子受体酪氨酸激酶抑制剂(epidermal growth factorreceptor tyrosine kinase inhibitors, EGFR-TKIs)治疗过程中血清多肽的变化并探索其临床意义。. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.