For TP53, however, the type of mutation mattered (Supplementary Fig. 3) with obvious deleterious variants such as frameshifts (n=19, MWU P=0.002) and nonsense substitutions (n=19, MWU P<0.0001) clearly showing lower expression, while increased expression of TP53 was found in samples with missense substitutions (n=47, MWU P<0.0001) supportive of a potential tumour promoting role of some of these latter type of TP53 variants20. The gene discussed is TP53; the disease is neoplasm.