SOST and osteoporosis: This is in contrast to a study that compared serum sclerostin levels in healthy controls and/or patients with osteoporosis to patients with OA27 where no significant difference was found (0.78 vs 0.71 vs 0.80 ng/ml) between these groups, as well as to the findings of Amrein et al. that serum sclerostin levels do not linearly correlate with fracture risk52.