Furthermore, to clarify whether the DNA repair genes have different correlations between CNA and mRNA in tumours of distinct subtypes or stages, we performed the same analysis separately for each estrogen receptor (ER)-based subtype and for each tumour stage (Stage IV was not included as it is represented by only eight samples); the results (Supplementary Figures S1 and S2) are similar to those in Fig. 1. The gene discussed is ESR1; the disease is neoplasm.