GPT and Cirrhosis: Five factors, including age (P = 0.002), cirrhosis (P = 0.003), ALT/AST ratio (P = 0.034), rs2132039 genotype (P = 0.012) and treatment methods (P < 0.001), were significantly associated to time-to-HBeAg seroconversion in the univariate analysis (Table 3).