Independent factors associated with HCV SVR were male (OR: 5.91, 95% CI: 1.46–23.9, P = 0.013) in genotype 1 patients, and AFP > 20ng/ml (OR:0.11, 95% CI: 0.02–0.78, P = 0.027), liver cirrhosis (OR:0.22, 95% CI: 0.06–0.86, P = 0.029) in genotype 2 patients. This evidence concerns the gene AFP and cirrhosis of liver.