TH and Allan-Herndon-Dudley syndrome: Taking advantage of this robust assay in live animals, we tested the effect of the TH analogs DITPA and TRIAC as potential treatments for hypomyelination in AHDS, and found that both drugs can prevent the occurrence of hypomyelination in mct8−/− embryos, and TRIAC can completely rescue hypomyelination in the larvae even after damage was apparent.