AFF1 and acute lymphoblastic leukemia: a-DMRs that overlapped with previous studies include: an intragenic region within AFF1, the 3′ portion of the oncogenic fusion gene causative in acute lymphoblastic leukaemia [58] (Additional file 3: Figure S1j); the promoter CpG Island shore region of the transcription factor KLF9 induced by oxidative stress [59]; and the ZNF577 a-DMR mentioned above with respect to PCV.